StayActiv^®: a Natural Alternative to Pain-Relieving Drugs

StayActiv is a revolutionary advancement in natural pain relief. It contains a blend of natural amino acids that provides anti-inflammation and pain relief equivalent to drugs in the NSAIDs class, without the harmful side effects. NSAIDs are non-steroidal anti-inflammatory drugs, which include ibuprofen.

Unlike StayActiv, NSAIDs can cause:

• Stomach ulcers
• Gastro-intestinal bleeding
• Slow-down of protein synthesis, a key to muscle and tissue healing

What the Research Shows

Safety, toxicity, and necropsy studies performed at the University of Missouri Medical Center showed no negative side effects or contraindications for StayActiv, even when dosed at super-therapeutic levels of 30 times the recommended amount. All safety data has been submitted to the U.S. Food and Drug Administration (FDA).

How StayActiv Works Against …

Prostaglandin Production

The effects of StayActiv on the production of prostaglandin, which causes pain and inflammation, are continuing to be evaluated. But the initial assessments are that StayActiv’s effectiveness, or efficacy, is related to the stabilization of mitochondrial membranes. A stabilized mitochondria is less susceptible to damage and injury. As reported in Arthritis and Rheumatism volume 58, page 2409, 2008, damage to the mitochondria of human chondrocyte cells results in increased levels of prostaglandin production.

Mitochondrial Dysfunction

Additional recent inflammation research supports mitochondrial dysfunction as the central, common, pathway for inflammation. So a treatment that stabilizes mitochondrial function can be soundly hypothesized as preventing cellular inflammation. This view is gaining acceptance in treating both classical inflammatory diseases such as arthritis and neuro-degenerative-based conditions such as Alzheimer’s disease.

Free Radicals

It is also widely accepted that oxidation of lipids and proteins in the body lead to inflammation. This is due to the formation of oxygen free radicals, which are negatively charged reactive oxygen species (ROS). If not detoxified, these ROS will go on to cause destruction and degradation in proteins, lipids and DNA/RNA. An increase in free radicals in tissue causes it to become inflamed. A cascade of pro-inflammatory events and chemical messengers are set in motion that attracts more immune cells into the area to fight the cause of the inflammation and to restore cellular order. The inflammation progresses until the problems are removed or repaired, or inflammation may progress until it causes cellular damage itself, resulting in cell death.

A Vicious Cycle

A key location for generating the oxygen-free radicals is the mitochondria. These organelles, due to the metabolic work of the cell, use a significant amount of oxygen for the oxidation and reduction reactions that take place within. When the mitochondria become damaged from the oxygen free radicals, one of the by-products is the formation of lipid-free radicals in the mitochondrial membrane. These in turn activate the prostaglandin system, which in turn activates and reacts to various inflammatory cytokines that are being released.

Enter StayActiv …

Initial scientific assessment indicates that StayActiv’s ability to increase the stability of the mitochondria helps the body withstand the pro-inflammatory events that lead to a loss of mitochondrial membrane function, which then catalyzes the inflammatory process in the cell. By attacking the inflammatory cascade at the start - in the mitochondria – StayActiv can prevent the cascade of cellular inflammatory events that causes cell injury and related side effects.